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MEMCARE-SRC Speaker Series 09/21, Quan Lu, Extracellular Vesicles in Environmental Health and Diseases - Shared screen with speaker view
Yong Li
01:08:29
how about the toxicity from the ARMMs? e.g. delivery of WT p53 into mice may cause apoptosis in cells in normal tissues.
Paul Westerhoff
01:16:17
What would you predict to happen when you have mixtures of metals - arsenic + something else (e.g., Mn or Chromium)?
Paul Westerhoff
01:16:42
Would you expect same pattern as arsenic?
Paul Westerhoff
01:17:30
Great -thanks
Ryan Hogans
01:17:37
Are other non-coding RNAs being investigated by your group as part of the research in EVs?
Angelica Ortiz
01:18:12
have you examined what sort of EVs are favored for release following metal exposures (exosomes, ARMMs, microvesicles)?
Nancy Denslow
01:18:12
How do exosomes contribute or not to your studies
Blanca Rodriguez (she/her)
01:19:35
do ARMM EVs differ from exosomes mainly based on the presence of the ARRCD protein or are there other different cargo that stand out between these two types of EVs?
Angelica Ortiz
01:21:09
How are ARMMs primarily incorporated by recipient cells? Is there an activation of clathrin/calveolin-mediated endocytosis or are then incorporated by plasma membrane fusion?
Jessy Deshane
01:21:30
Have you used any specific antibody-based column purification strategies to differentiate exosomes from ARMMs
YZ
01:23:10
How is the functional association or connection between ARRCD 1 and ARRCD1 may like? Since they seem like to play kind of specific roles in regulating the process of virus budding ?
Jessy Deshane
01:24:00
Once ARMMs are internalized, are they targeted to lysosome or endosome of the recipient cells
YZ
01:25:58
Sorry ARRCD3
Angelica Ortiz
01:27:28
I saw that overexpression of ARRDC1 increases EV release by cells. Is there an increase in ARRDC1 in cells following metal exposure?
Barchowsky, Aaron
01:28:21
Outstanding work and look forward to learning more about the ARMMs, exosomes in metals toxicology in the future. Thank you
Shan
01:30:21
Thank you!