The 2020 Nagorno-Karabakh war and Russia-brokered peace agreement put an end to the status quo that had been in place since 1994. They ushered in a new political and security configuration in the South Caucasus, with more direct involvement by Turkey and Russia, and beyond. For many years, the United States, along with other international actors, has been engaged in efforts to resolve the deep-rooted conflict, most notably the Minsk Group that was comprised of the United States, France and Russia under OSCE auspices. Now it might need to readjust its approach. This panel of scholars and practitioners/diplomats will discuss the new situation and its implications for the region and international involvement.